Key publications

  • A phase 2 trial of lomeguatrib and temozolomide in metastatic colorectal cancer (2008). Omar A Khan, Malcolm Ranson, Michael Michael, Ian Olver, Nicola C Levitt , Peter Mortimer, Amanda J Watson, Geoffrey P Margison, Rachel Midgley, Mark R Middleton. Br J Cancer 98:1614-8.
  • Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemoradiation for locally advanced pancreatic cancer (2008). Brunner TB, Geiger M, Grabenbauer GG, Lang-Welzenbach M, Mantoni TS, Cavallaro A, Sauer R, Hohenberger W, McKenna WG. J Clin Oncol. 26(16):2699-706.
  • Arginine methylation regulates the p53 response (2008). Jansson M, Durant ST, Cho EC, Sheahan S, Edelmann M, Kessler B, La Thangue NB. Nat Cell Biol. 10(12):1431-9.
  • Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells (2008). Emaduddin M, Edelmann M, Kessler B, Feller S. Cell Comm. Signalling. 9;6-7.
  • ATM and Chk2 kinase target the p53 co-factor Strap (2008). Adams CJ, Graham AL, Jansson M, Coutts AS, Edelmann M, Smith L, Kessler B, La Thangue NB. EMBO Rep. 9(12):1222-9.
  • NovelMMP-9 substrates in cancer cells revealed by a label-free quantitative
  • proteomics approach (2008). Xu D, Suenaga N, Edelmann MJ, Fridman R, Muschel MJ, Kessler BM. Mol. Cell. Proteomics. 7(11):2215-28.
  • Conventional radiotherapy or hypofractionation?: A study of molecular changes resulting from different
  • radiation fractionation schemes (2009). Hamilton J, Higgins G, Bernhard EJ.. Cancer Biol Ther 8;774-776.
  • Comparison of CID versus ETD based MS/MS fragmentation for the analysis of protein ubiquitination. Sobott F, Watt SJ, Smith J, Edelmann MJ, Kramer HB, Kessler BM. J Am Soc Mass Spectrom. In press.
  • Radio-embolization of liver metastases from colorectal cancer: Rational Combination with Systemic Therapy.  Nicolay N, Berry DP, Sharma RA. Nature Rev Clin Oncol, in press.
  • Predicting the myelotoxicity of chemotherapy: the utility of pre-treatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mononuclear cells (2009). Ami Sabharwa1, Rachel Waters, Sarah Danson, Andrew Clamp, Paul Lorigan, Nick Thatcher, Geoffrey P. Margison, and Mark R. Middleton. Melanoma Res in press.
  • A phase I study of extended dosing with lomeguatrib with temozolomide in patients with advanced melanoma (2009). Richard F Kefford, Nicholas PB Thomas, Philippa G Corrie, Cheryl Palmer, Ehtesham Abdi, Dusan Kotasek, Jane Beith, Malcolm Ranson, Peter Mortimer, Amanda J Watson, Geoffrey P Margison, Mark R Middleton. Br J Cancer 100:1245-9.