Key publications
Pollard AJ, Perrett KP, Beverley PC, Maintaining protection against invasive bacteria in childhood with protein–polysaccharide conjugate vaccines. Nature Reviews of Immunology In Press. 2009
Snape MD, Kelly DF, Lewis S, Banner C, Kibwana L, Moore CE, Diggle L, John T, Yu LM, Borrow R, Borkowski A, Nau C, Pollard AJ. Seroprotection against serogroup C meningococcal disease in adolescents in the United Kingdom: observational study. BMJ. 2008 Jun 28;336(7659):1487-91. Epub 2008 Jun 5
Sander CR, Pathan AA, Beveridge NE, Poulton I, Minassian A, Alder N, Van Wijgerden J, Hill AV, Gleeson FV, Davies RJ, Pasvol G, McShane H. Safety and Immunogenicity of a New TB Vaccine, MVA85A, in M. tuberculosis Infected Individuals. Am J Respir Crit Care Med. 2009 Jan 16.
Snape MD, Maclennan JM, Lockhart S, English M, Yu LM, Moxon RE, Pollard AJ. Demonstration of Immunologic Memory Using Serogroup C Meningococcal Glycoconjugate Vaccine Pediatr Infect Dis J. 2009 Jan 7. [Epub ahead of print]
Pace D, Snape M, Westcar S, Oluwalana C, Yu LM, Begg N, Wysocki J, Czajka H, Maechler G, Boutriau D, Pollard AJ. A novel combined Hib-MenC-TT glycoconjugate vaccine as a booster dose for toddlers: a phase 3 open randomised controlled trial. Arch Dis Child. 2008 Nov;93(11):963-70. Epub 2008 May 7.
Blanchard-Rohner G, Pulickal AS, Jol-van der Zijde CM, Snape MD, Pollard AJ, Appearance of peripheral blood B cells and antibodies in a primary and secondary immune response in humans. Submitted to European J Immunol. 2009
Brocklebank D, Pettersson F, Broxholme J, Hill AV, Morris AP, Pollard AJ, van der Sande MA, Sirugo G, Moore CE, Hennig BJ. Population structure in West Africans and North West Europeans: a comparison with HapMap data from Yoruba and CEPH. Drafted for BMC Genetics Jan 2009.
Callaghan, MJ, Lewis, S, Sadarangani, M, Bailey, S, Chan, H, Ferguson, D. Derrick, JP, Feavers, I, Maiden, MC, Pollard, AJ. Evaluation of recombinant Opa proteins as vaccine candidates against hyperinvasive meningococci. Drafted for Infect Imm 2009.
Klinger CL, Snape MD, John T, Layton H, Pestridge S, Dymond S, Galiza E, Daniels E, Tansey S, Scott D, Baker S, Yu LM, Faust SN, Finn A, Heath PT, Pollard AJ , Incorporating a 13-valent pneumococcal conjugate vaccine into the UK immunisation schedule: a double blind randomised active controlled trial. Drafted for BMJ 2009
Jäkel A, Plested JS, Hoe JC, Makepeace K, Gidney MA, Lacelle S, St Michael F. Cox AD, Richards JC, Moxon ER. Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures. Vaccine. 2008; 185(11): 3270-7
Plüddemann A, Hoe JC, Makepeace K, Moxon ER, Gordon S. The Macrophage Scavenger Receptor A is host-protective in experimental meningococcal septicaemia. PLOS Pathogens in press
Draper SJ, Goodman AL, Biswas S, Forbes EK, Moore AC, Gilbert SC, Hill AV. Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malaria. Cell Host Microbe. 2009 Jan 22;5(1):95-105.
Berthoud TK, Dunachie SJ, Todryk S, Hill AV, Fletcher HA. MIG (CXCL9) is a more sensitive measure than IFN-gamma of vaccine induced T-cell responses in volunteers receiving investigated malaria vaccines. J Immunol Methods. 2009 Jan 1;340(1):33-41. Epub 2008 Oct 24.
Beveridge NE, Fletcher HA, Hughes J, Pathan AA, Scriba TJ, Minassian A, Sander CR, Whelan KT, Dockrell HM, Hill AV, Hanekom WA, McShane H. A comparison of IFNgamma detection methods used in tuberculosis vaccine trials. Tuberculosis (Edinb). 2008 Nov;88(6):631-40. Epub 2008 Sep 17.
Boosting BCG vaccination with MVA85A down-regulates the immunoregulatory cytokine TGF-beta1. Fletcher HA, Pathan AA, Berthoud TK, Dunachie SJ, Whelan KT, Alder NC, Sander CR, Hill AV, McShane H. Vaccine. 2008 Sep 26;26(41):5269-75. Epub 2008 Aug 3.
Draper SJ, Moore AC, Goodman AL, Long CA, Holder AA, Gilbert SC, Hill F, Hill AV. Effective induction of high-titer antibodies by viral vector vaccines.. Nat Med. 2008 Aug;14(8):819-21. Epub 2008 Jul 27.
Thompson FM, Porter DW, Okitsu SL, Westerfeld N, Vogel D, Todryk S, Poulton I, Correa S, Hutchings C, Berthoud T, Dunachie S, Andrews L, Williams JL, Sinden R, Gilbert SC, Pluschke G, Zurbriggen R, Hill AV. Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial. PLoS ONE. 2008 Jan 30;3(1):e1493.
Todryk SM, Hill AV. Malaria vaccines: the stage we are at. Nat Rev Microbiol. 2007 Jul;5(7):487-9.
Pulickal AS, Pollard AJ. Vi polysaccharide-protein conjugate vaccine for the prevention of typhoid fever in children: hope or hype? Expert Rev Vaccines. 2007 Jun;6(3):293-5.
Granoff DM, Pollard AJ. Reconsideration of the use of meningococcal polysaccharide vaccine. Pediatr Infect Dis J. 2007 Aug;26(8):716-22
Pace D, Snape M, Westcar S, Hamaluba M, Yu L, Begg N, Wysocki J, Czajka H, Maechler G, Boutriau D, Pollard AJ, A new combination Haemophilus influenzae type b and Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine for primary immunisation of infants. Paediatric Infectious Disease Journal 2007 Nov;26(11):1057-1059
Callaghan, M.J, Rockett, K, Banner, C,Haralambous, E, Betts H, Faust, S, Maiden, M.C.J, Kroll, J.S, Levin, M, Kwiatkowski, D.P, Pollard, A.J. Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease. Genes and Immunity 2008 Jan;9(1):30-7. Epub 2007 Oct 25
Pollard AJ. Hepatitis B vaccination. BMJ. 2007 Nov 10;335(7627):950
John TM, Hope T, Savulescu J, Stein A, Pollard AJ, Children's consent and paediatric research; is it appropriate for healthy children to be the decision-maker in clinical research? Arch Dis Child. 2008;93:379-383. Dec 18; [Epub ahead of print]
Clutterbuck EA, Oh S, Hamaluba M, Westcar S, Beverley PCL, Pollard AJ. Serotype specific and age dependent generation of pneumococcal polysaccharide specific memory B cells and antibody in response to immunization with a pneumococcal conjugate vaccine. Clinical and Vaccine Immunology 2008 Feb;15(2):182-93. Epub 2007 Nov 21
Blanchard Rohner G, Snape M, Kelly DF, Waterhouse T, Morant A, Yu L, Borkowski A, Ceddia F, Borrow R, Siegrist CA, Pollard AJ. The magnitude of germinal center priming with a protein-polysaccharide conjugate vaccine in human infants determines the persistence of antibody and the intensity of booster response. Journal of Immunology 2008;180(4):2165-73.
Snape MD, Perrett KP, Ford KJ, John TM, Pace D, Yu L, Langley JM, McNeil S, Dull P, Ceddia F, Anemona A, Halperin SA, Dobson S, Pollard AJ. A randomized controlled trial of a novel tetravalent meningococcal glycoconjugate vaccine in infants.JAMA 2008 Jan 9;299(2):173-84
Lee YC, Kelly DF, Yu LM, Slack MP, Booy R, Heath PT, Siegrist C-A, Moxon ER, Pollard AJ, Haemophilus influenzae type b vaccine failure in children is associated with inadequate production of high quality antibody. Clinical Infectious Disease, 2008 Jan 15;46(2):186-92.
Oh SY, Griffiths D, Waterhouse T, Lee YC, Yu LM, McCarthy N, Heath PT, Crook D, Ramsay M, Moxon ER, Pollard AJ, School-age children: a reservoir for continued circulation of Haemophilus influenzae type b in the UK. Journal of Infectious Disease 2008 May 1;197(9):1275-81.
Pulickal AS, Hambleton S, Callaghan MJ, Moore CE, Goulding J, Goodsall A, Baretto R, Lammas DA, Anderson ST, Levin M and Pollard AJ Biliary Cirrhosis in a Child with Inherited Interleukin-12 Deficiency, Tropical Paediatrics 2008 Aug;54(4):269-71. Epub 2008 Jan 19.
Warrell MJ, Riddell A, Yu L-M, Phipps J, Diggle L, Bourhy H, Deeks J J, Fooks AR, Audry L, Brookes SM, Meslin F-X, Moxon ER, Pollard AJ and Warrell DA, A Simplified 4-site Economical Intradermal Post-exposure Rabies Vaccine Regimen: a Randomised Controlled Comparison with Standard Methods. PloS Neglected Tropical Disease. 2008 Apr 23;2(4):e224
Rohner GB, Pollard AJ. Sustaining immunity after immunisation against encapsulated bacteria. Hum Vaccin. 2007 Dec 17;4(4)
Kelly DF, Snape MD, Perrett K, Clutterbuck EA, Blanchard-Rohner G, Jones M, Yu L and Pollard AJ. Plasma and memory B cell kinetics in infants following a primary schedule of CRM197 cojugated serogroup C meningococcal conjugate vaccine. In Press Immunology 2008
Callaghan MJ, McCarthy ND, Pavon ABI, Faust S, Gray SJ, Kaczmarski EB, Levin M, Kroll JS, Maiden MCJ, Pollard AJ The Opa protein repertoires of disease-causing and carried meningococci: genetic diversity and association with clinical severity. J Clin Microbiol. 2008 Sep;46(9):3033-41. Epub 2008 May 28.
Kelly DF, Moxon ER, Yu LM, Pollard AJ. Haemophilus influenzae type b (Hib) anti-PRP antibody concentration and avidity index in 3-5 year old children since start of infant Hib immunisation in the UK. Clin Vaccine Immunol. 2008 Sep 10. [Epub ahead of print]
